Tirzepatide
$105 AUD
For laboratory research use only. Not for human consumption. Must be handled by qualified researchers in accordance with applicable regulations.
Overview
Tirzepatide (LY3298176) is a synthetic 39-amino-acid fatty acid-acylated peptide that functions as a dual agonist at both the glucose-dependent insulinotropic polypeptide receptor (GIPR) and the glucagon-like peptide-1 receptor (GLP-1R). Based on the native GIP sequence with GLP-1R-activating modifications, Tirzepatide has received regulatory approval in several jurisdictions for type 2 diabetes and obesity management.
Scientific Overview
Research has positioned Tirzepatide at the forefront of incretin-based metabolic therapy investigation. Phase 3 clinical trials (SURMOUNT, SURPASS programmes) have demonstrated substantial weight reduction and glycaemic improvement in adults with obesity and type 2 diabetes. Research has also examined its effects on liver fat, NASH, cardiovascular risk markers, obstructive sleep apnoea models, and chronic kidney disease progression. The contribution of GIPR agonism to its efficacy above GLP-1R agonism alone has been an active area of mechanistic investigation.
Mechanism of Action
Tirzepatide activates GIPR and GLP-1R via Gs-coupled adenylyl cyclase, elevating intracellular cAMP in pancreatic beta cells to enhance glucose-dependent insulin secretion and in alpha cells to suppress glucagon release. GLP-1R activation in the hypothalamus and brainstem reduces appetite and delays gastric emptying. GIPR agonism in adipocytes and the CNS may contribute to enhanced fat oxidation and improved insulin sensitivity beyond GLP-1R effects alone. The dual mechanism produces a synergistic reduction in postprandial glucose excursions and cumulative caloric intake in metabolic research models.
Areas of Research
Third-Party Testing
Every batch of Tirzepatide supplied by Pure Recovery Labs is independently analysed by a third-party laboratory prior to release. Purity is confirmed via HPLC and mass spectrometry to a minimum of 99%. A certificate of analysis is accessible via QR code on each product and through the Quality page.
Research Use Only
Tirzepatide is supplied exclusively for in vitro and preclinical laboratory research. It is not intended for, and must not be used in, humans or animals. It is not a medicinal product, therapeutic agent, supplement, cosmetic, or food substance. All handling must comply with applicable institutional and regulatory requirements. Pure Recovery Labs makes no claims regarding therapeutic efficacy or safety in any biological system.